Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy

Background and Aim: Oxidative stress, caused by environmental insults, may interfere with redox signaling during pregnancy is a known contributor to preterm birth. In vivo in vitro studies indicate that PFAS generate reactive oxygen species, but this has been minimally investigated humans not examined pregnancy. We the effects of prenatal exposure on oxidative stress biomarkers, hypothesizing would be positively associated stress. Methods: Our analytic sample included participants enrolled Illinois Kids Development Study Chemicals Bodies prospective cohorts between 2014 2019 (N=428). Seven were quantified 2nd trimester serum. Urine levels 8-isoprostane-prostaglandin-F2α, PGF2α, 2,3-dinor-8-iso-PGF2α, 2,3-dinor-5,6-dihydro-8-iso-PGF2α measured 3rd trimesters as biomarkers fit linear mixed-effects models estimate associations single one or two measurements biomarkers. used quantile g-computation Bayesian kernel machine regression (BKMR) assess mixture multiple All adjusted for cohort, maternal age, parity, education, pre-pregnancy body mass index. Results: Linear showed an interquartile range increase perfluorooctane sulfonic acid (PFOS) was 4.08% 8-iso-PGF2α (95% confidence interval [CI]= -3.20, 11.91). Using g-computation, one-quartile all concentrations modest (β=0.09, 95% CI= -0.07, 0.25). both BKMR, across PFOS contributed most overall effect. Conclusions: study first investigate Findings consistent methods indicated elevated among pregnant people.